Rejuran as A DNA Salmon–Based Skin Booster Innovation for Skin Regeneration

In recent years, non-invasive aesthetic treatments have become increasingly popular due to their ability to improve skin health without prolonged downtime. One treatment widely recommended by aesthetic doctors and dermatologists is Rejuran, an injectable treatment that focuses on skin regeneration at the cellular level. This approach is what positions it as a regenerative aesthetic treatment, rather than merely a cosmetic procedure.

What Is Rejuran?

Rejuran is an injectable treatment developed to repair and revitalize the skin by enhancing its natural regenerative capacity. Originating from South Korea, this product is developed by PharmaResearch, a biopharmaceutical company well known for its research in regenerative technology.

The main active ingredient is polynucleotide (PN) extracted from salmon DNA. The biological structure of PN closely resembles human DNA, making it safe and highly biocompatible with skin tissue.

The primary focus of this treatment is not to deliver instant cosmetic results, but to help the skin become healthier, stronger, and more balanced from within.

How Does Rejuran Work on the Skin?

The mechanism of action of Rejuran is fundamentally different from hydration-based skin boosters. Once injected into the dermal layer, polynucleotides work through several key processes:

1. Stimulating Skin Cell Regeneration

PN supports the repair of damaged tissue, helping accelerate skin cell regeneration—especially in skin affected by premature aging, acne scars, or environmental stress.

2. Enhancing Collagen Production

Collagen is a key structural component that maintains skin elasticity and strength. With proper stimulation, the skin produces collagen naturally and sustainably.

3. Repairing the Skin Barrier

Rejuran helps restore the skin’s natural protective barrier, making it more resilient against pollution, UV exposure, and irritation.

4. Reducing Micro-Inflammation

Sensitive or problematic skin often experiences chronic low-grade inflammation. PN has soothing properties that help rebalance skin conditions.

As a result, the skin not only appears brighter but also has a smoother texture and a more stable condition in the long term.

Skin Benefits of Rejuran

This treatment is commonly recommended by doctors for various skin concerns, including:

• Dull and lackluster skin

• Uneven skin texture

• Mild acne scars

• Fine lines caused by aging

• Sensitive or easily irritated skin

• Weakened skin barrier

Due to its regenerative nature, Rejuran is often combined with other aesthetic procedures to enhance overall treatment outcomes.

How Rejuran Differs from Other Skin Boosters

Although Rejuran is administered via injection like other treatments, there are several fundamental differences worth understanding.

1. Active Ingredients

Most skin boosters on the market use hyaluronic acid (HA) as their main component. HA functions by attracting and retaining water, making the skin appear more hydrated and plump.

Rejuran does not rely on HA as its primary ingredient. Instead, it uses polynucleotides that work at the cellular level to repair skin tissue.

2. Long-Term Results

The hydrating effect of HA is temporary and diminishes over time. In contrast, Rejuran gradually improves overall skin quality, resulting in more natural and longer-lasting outcomes when performed according to proper treatment protocols.

Types of Rejuran

1. Rejuran Healer

Rejuran Healer is the most commonly used variant. It is formulated to improve overall skin quality, including texture, elasticity, and skin barrier health. This variant is frequently recommended for dull skin, early signs of aging, mild acne scars, and skin stressed by environmental factors.

2. Rejuran S

Rejuran S has a thicker consistency and is designed for areas with more specific tissue damage, such as deeper acne scars or uneven skin texture. This variant provides more targeted structural skin repair compared to the standard formulation.

3. Rejuran i
   Rejuran i is specifically designed for the delicate eye area, where the skin is thinner and more sensitive. It helps improve the appearance of fine lines, dryness, and signs of fatigue in the periorbital area without causing heaviness or overcorrection.

3. Rejuran HB Plus
   The latest variant that improves skin texture, soothes inflammation, and reduces early signs of aging. It provides deep hydration for an instant "glass skin" effect, making it the ideal solution for dry skin requiring intensive hydration.

With multiple variants available, doctors can tailor Rejuran treatments more precisely to each patient’s individual needs.

Is Rejuran Safe?

Safety is a critical aspect of any injectable treatment. Rejuran has undergone various clinical studies and is widely used in South Korea and other countries. Due to its high biocompatibility, the risk of allergic reactions is relatively low when administered by trained medical professionals.

However, the procedure should always be performed by an experienced doctor to ensure proper injection technique and appropriate patient selection.

Conclusion

Rejuran offers a distinct approach in aesthetic skin treatments by focusing on regeneration rather than hydration alone. With polynucleotide derived from salmon DNA as its key ingredient, this treatment helps improve skin quality from within, making it an attractive option compared to conventional skin boosters. For individuals seeking long-term skin health rather than instant cosmetic results, Rejuran is a highly suitable choice.